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Sunday
May 28th
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Registration
(15.00 onward)
Welcome
Reception (20.00 on ward)
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Monday
May 29th
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9.00-11.15 |
Death in
Cancer Chairs
- Jan Paul Medema and Ricky Johnstone |
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Ricky Johnstone, Defining
the apoptotic pathways underlying histone
deacytelase inhibitor-mediated tumor therapy.
Elza de Bruin,
Role of intrinsic and radiotherapy-induced
apoptosis in rectal cancer patients.
Dario Lombardi, Cytotoxic
activity of normal and cancer neural stem cells
through the production of death receptor ligands.
Arturo Sala, The double life
of ApoJ/clusterin: an antiapoptotic protein
inhibitor of neuroblastoma metastasis.
Mileidys Perez Alea, Cancer
stem cells contribute to the aggressive
behaviour of human epithelial colon cancer.
Maria Giovanna Francipane,
Autocrine production of IL-4 confers resistance
to chemotherapy and CD95-induced cell death in
cancer cells.
Valeria
Coppola, miR-15
and miR-16 induce apoptosis by targeting BCL2 in
prostate cancer.
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11.15-11.45 |
coffee
break
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11.45-13.15 |
Alternative
Pathways
Chairs
- Eric Baehrecke and Marja Jäättelä
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Catherine
Stenson, A more serine way to die? Investigating the role of serine
proteases in leukaemic cell death.
Mads
Gyrd-Hansen, Apoptosome-independent activation of lysosomal cell death
pathway by caspase-9.
Mads
Daugaard, Hsp70-2 controls the expression level of a potent cancer
cell survival protein, Lens Epithelium Derived
Growth Factor (LEDGF/p75).
Mélanie
Denizot, Autophagy is involved in CD4+ T cell death triggered by
HIV-1 envelope proteins.
Katja
Simon, Autophagy and the immune system in vivo.
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13.15-14.45 |
lunch
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14.45-16.00 |
Alternative Pathways (discussion session)
Chairs -
Eric Baehrecke and Marja Jäättelä
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Eric
Baehrecke,
Genetic regulation of autophagic programmed cell
death.
Marja
Jäättelä,
Disruption of the lysosomal pH gradient combined
with the inhibition of autophagosome formation,
a new strategy for anti-cancer therapy?
Discussion
on the role of alternative pathways in cell
death
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16.00-20.00 |
Poster
Session + drinks
Posters
(names A-L)
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20.00 |
dinner
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Tuesday
May 30th
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9.00-11.00 |
Caspase Regulation and
Targets
Chairs
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Ina
Lavrik, The role of two new c-FLIP proteins in life and death of cells.
Aura
Kaunisto, Specific phosphorylation regulates the ubiquitylation and
turnover of c-FLIP(S)
Christina
Falschlehner, Caspase-3 and BID are differentially processed by Caspase-8
and Caspase-10.
Rüdiger
Arnold, The caspase-3 target HPK1: A Molecular Switch between Life and Death in
Hematopoietic Cells.
Magnus
Olsson, A functional connection between p53 and Caspase-2 is essential for
apoptosis induced by DNA damage.
Gavin
McStay, In situ trapping of activated initiator caspases reveals a role for
caspase-2 in heat shock-induced apoptosis.
Enrique
Pérez-Payá, Small molecule inhibitors of apaf-1-related caspase-3/-9
activation that control mitochondrial-dependent
apoptosis.
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11.00-11.30 |
coffee
break
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11.30-13.15
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Death
Receptors
Chairs
–
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Thomas
Kaufmann,
Pro-Apoptotic BH3-only Bcl-2 Family Member Bid
Is Required for FasL- but not for TNF-Mediated
Fatal Hepatocyte Death and Dispensable for DNA
Damage-Induced Apoptosis and Cell Cycle Arrest.
Brian
Ferguson,
Structural and biochemical analysis of the death
domain complex formed at the Fas receptor.
Fiona
Kimberley,
Abnormal disulphide linked oligomers, global
misfolding and intracellular retention of
receptors underlies pathology in Tumour Necrosis
Factor Receptor Associated Periodic Syndrome (TRAPS).
Thomas
Brunner, Loss
of TRAIL protects from Fas (CD95)-induced
hepatoxicity and lethality.
Anne
Grosse-Wilde,
The apoptosis-inducing TRAIL-receptor is a
metastasis suppressor in a multi stage skin
tumor mouse model.
Marion
Macfarlane,
Receptor-selective trail mutants reveal that
primary lymphoid tumor cells signal to apoptosis
via TRAIL-R1: implications for therapy.
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13.30-14.30 |
lunch
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14.30-21.30 |
Trip
to castle + dinner
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Wednesday
May 31st
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8.45-11.00 |
BH3 molecules
Chairs
- Andreas Villunger and Philippe Bouillet
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Philippe
Bouillet,
Mouse models to decipher the role of the
BH3-only proteins in triggering apoptosis.
Verana Labi,
The BH3-only protein Bmf has overlapping
functions with Bim during cell death induction
and B-cell development.
Paul Ekert,
Cell death provoked by loss of Interleukin-3
signalling is independent of Bad, Bim, and PI3
Kinase/AKT, but depends in part on Puma.
Stephen Tait, Unconventional
ubiquitination of Bid is required for its
pro-apoptotic activity.
Miriam Erlacher,
Combined loss of Bim and Puma mirrors the
effects of Bcl-2 overexpression in some but not
all forms of cell death.
Eric Eldering,
Distinct expression levels of Noxa in peripheral
versus lymph node chronic lymphocytic leukemia
cells are linked with survival capacity.
Nuno Lages Alves,
The Noxa/Mcl-1 axis regulates susceptibility to
apoptosis under glucose limitation in dividing T
cells.
Bernhard Gillisen,
Nbk induces apoptosis via an ER pathway in a
Bax-dependent manner.
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11.00-11.30 |
coffee
break
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11.30-13.30 |
Mitochondrial
Structure and Death
Chairs
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Lisa
Bouchier-Hayes, Bax-mediated membrane permeabilization can occur in cells in the absence
of mitochondrial membrane proteins.
Jerry
Chipuk,
Mitochondrial outer membrane permeabilization is
directly regulated by the mitochondrial fission
machinery.
Cristina
Muñoz-Pinedo, Coordinate release of mitochondrial inter-membrane space proteins during
apoptosis revealed by real time single cell
analysis.
Patrice
Petit,
Cloning of the human cardiolipin synthase and
effects of its knowkdown on cell death
progression : a switch between apoptosis and
necrosis.
Eric C.C.
Cheung,
Dissociating the dual roles of apoptosis
inducing factor (AIF) in apoptosis and
maintaining mitochondrial structure.
Franziska
Mullauer,
Betulinic acid induced cell death in cancer
cells.
David Dickens, Identification of MAP4K3 as a putative tumor
suppressor using an RNAi screen.
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13.30-15.00 |
lunch
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15.00-16.00 |
BH3-Mitochondria (discussion session)
Andreas Villunger
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16.00-20.00 |
Poster Session + drinks
Posters (names M-Z)
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20.00 |
dinner
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Thursday
June 1st
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9.00-10.45 |
Nuclear Aspects of “Death” Chairs - |
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Vincenzo
De Laurenzi,
FLASH is an essential component of cajal bodies
and is required for histone transciption and
S-phase progression.
Brent
Derry,
Regulation of p53 by multiple SCF-based E3
ligases in C. elegans.
Catarina
Grandela,
Regulation of apoptosis of by p53 in human
embryionic stem cells.
Paolo
Salomoni,
The role of Daxx in stress-induced cell death.
Paul
Townsend,
STAT-1: a modulator of apoptosis and cell cycle
checkpoint responses.
Michael
Ausserlechner, Regulation of Puma/bbc3
and Bcl-2 by p16INK4A sensitizes leukemia cells
to Glucocorticoid- and Fas-induced apoptosis.
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10.45-11.15 |
Lymphocyte-Associated Death
Chairs - Nigel Watherhouse
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Ueli
Nachbur,
Post-transcriptional regulation of FasL killing
activity by lipid rafts.
Ilia
Voskoboinik, Unravelling
the mechanism and function of perforin, a key
effector molecule of the cytotoxic lymphocytes.
Nigel
Waterhouse, Inhibition
of caspases blocks granzyme B induced apoptosis
in Bcl-2 over-expressing cells and promotes
clonogenic survival
Michael
Bots,
The role of serine protease inhibitor SPI-6 in
dendritic cells.
Carmen Ruiz-Ruiz, Regulation of primary T lymphocytes resistance to
TRAIL-induced apoptosis
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13.00-14.30 |
lunch |
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14.30-16.00 |
IAP family members
Chairs -
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John Silke,
Role
of IAPs in TNF superfamily (TNFSF) signaling.
Martin
Leverkus,
Inhibition of IKK2 sensitizes human
keratinocytes to (TNF)-induced apoptosis
independent of cIAP2 upstream or at the level of
caspase 8.
Markus
Rehm, Effector
caspase activation as an all-or-none response
and its control by X-linked inhibitor of
apoptosis protein (XIAP) - a quantitative
systems biology analysis.
Paulo
Ribiero,
DIAP2, The drosophila orthologue of XIAP,
controls the effector caspase DRICE through a
novel mechanism.
Davina
Twiddy,
The ~700-kDa apoptosome complex directly
processes caspase-7, which is then sequestered
by XIAP into a stable ~200-kDa complex.
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17.00-19.00 |
1st EWCD
Football Cup (mixed)
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20.00 |
BBQ and party
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Friday
June 2nd:
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departure
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