Programme

 

Tuesday 11th May:	Arrival and evening dinner
Wednesday 12th May:	7.30 - 9.00:  Breakfast
	9.00 - 11.00: Caspase-independent Death Chairs - Eric Baehrecke and Christophe Borner   Stephen Tait: Caspase-independent cleavage of Bid at aspartate is essential for DNA damage-induced apoptosis. Lucy Peltenburg: A serine protease is involved in the initiation of DNA damage-induced apoptosis. Lotti Egger: Caspase-independent, apoptosis-like cell death and phagocytosis mediated by serine proteases. Colin Adrain: Proteomic identification of novel Granzyme B substrates . Georg Duenstl: A serine protease-dependent mechanism of death receptor-induced apoptosis after caspase arrest. Nicole Fehrenbacher: Tumorigenesis-associated sensitization to tumor necrosis factor-mediated cell death depends on cathepsin B . Marie Stampe Andersen: A novel sigma2-receptor ligand as an inducer of caspase-independent death of cancer cells in vitro and in vivo.
	11.00 - 11.30: Coffee break
	11.30 - 13.15: Autophagy and others Chairs - Pascal Meier and Miguel Martins   Eric Baehrecke: Autophagy genes function in an alternative cell death pathway. Maria Høyer-Hansen: Bcl-2 inhibits autophagy via its localization to the ER. Jacques Landry: Heat shock-induced non-apoptotic cell death mediated by protein aggregation. Vanessa Zuzarte-Luis: BMP5- a new player in the control of interdigital cell death acting hrough Smad and MAPK signalling patwhays. Alvin Joselin: Functional characterization of ASAP complexes in Apoptosis and RNA processing. Michelangelo Campanella: The coxsackievirus 2B protein suppresses apoptotic host cell responses by manipulating intracellular Ca2+ homeostasis.
	13.15 - 15.00: Lunch
	15.00 - 16.15: Neuronal Death / Ischaemia I Chairs - Ruggero De Maria and Klaus Schulz-Osthoff   Katerina Sakoulas: Cytotoxicity of Cerebrospinal Fluid Samples from Human Infants with Cerebral Hypoxic-Ischaemic Injury Implicates CD95/Fas as a Major Component of the Inflammatory Response. Kevin Lawrence: The cardioprotective effect of urocortin during ischaemia/reperfusion involves the prevention of apoptosis and mitochondrial damage. Paul Townsend: BAG-1 proteins protect cardiac myocytes from simulated ischemia/reperfusion-induced apoptosis via an alternate mechanism of cell survival independent of the proteasome. Huseyin Mehmet: Developmentally Regulated Changes in Apoptotic Stress-induced c-Jun N-Terminal Kinase Activation in the Oligodendrocyte Lineage
	16.15 - 16.45: Coffee break
	16.45 - 18.00: Neuronal Death / Ischaemia II Chairs - Huseyin Mehmet and Anastasis Stephanou Stefan Klussmann: Therapeutic Neutralization of CD95 Ligand Prevents Apoptosis and Promotes Axonal Regeneration and Functional Recovery after Spinal Cord Injury . Adriana Eramo: TRAIL resistance of glioblastoma cells by epigenetic silencing of caspase 8. Susanne Kleber: New trials downstream of CD95 in the CNS. Lucia Ricci-Vitiani: Double level of protection from death receptors and inflammatory cytokines in neural stem cells.
	18.00-20.00: Posters 1 to 28
	20.00: Dinner
Thursday 13th May:	7.30 - 9.00:  Breakfast
	9.00 - 11.00: Immunology and Inflammation Chairs - Jan Paul Medema and John Silke   Douglas Green: A Physiological Function for TRAIL. Katharina Simon: Fas Ligand (FasL): an adjuvant to generate monoclonal antibodies that reject tumour . Lages Alves: Early induction of BH3-only protein Noxa in naïve CD8+ T cells after TCR triggering. Michel Hahne: Distinct functions for APRIL in regulation of humoral responses. Ajoy Samraj: The tyrosine kinase Lck is a positive regulator of the mitochondrial apoptosis pathway by regulating Bak expression. Alberto Bosque: The mitochondrial apoptotic pathway in perforin/granzyme-induced apoptosis mediated by CTL effectors.
	11.00 - 11.30: Coffee break
	11.30 - 12.45: Mitochondrial Pathways      Chairs - Marion MacFarlane and Giorgio Stassi   Andreas Villunger: An essential role for the BH3-only protein Bim in the establishment of central tolerance. Christoph Borner: Shuttling Bax from the cytosol to mitochondria: a complex business involving N- and C-termini. Gavin McStay: Identification of a novel post-translational modification of Apaf-1 after apoptosome activation. Cristina Muñoz-Pinedo: Mitochondrial intermembrane space proteins are released in a single step during apoptosis.
	12.45 - 14.00: Lunch
	14.00 - 19.00: Excursion to Istanbul
	20.00: Dinner
Friday 14th May:	7.30 - 9.00:  Breakfast
	9.00 - 10.45: p53 and Family Members Chairs – Eric Eldering and Arturo Sala   Jerry Chipuk: Direct Activation Of Bax By p53 Mediates Mitochondrial Membrane Permeabilization And Apoptosis. W. Brent Derry: Assembling the p53 network in C. elegans by functional genomics. Anastasis Stephanou: STAT1: a novel regulator of the apoptotic programme. Miriam Erlacher: PUMA/bbc3, a key mediator of p53-induced apoptosis. Hakan Akca: Cytokine-mediated induction of p53 and p21 is suppressed by EGF and insulin . Vincenzo De Laurenzi: Identification of proteins regulating p73 function.
	10.45 - 11.15: Coffee break
	11.15 – 13.15: Cancer I Chairs – Michel Hahne and Brent Derry   Peter Daniel: Synergy between TRAIL and DNA damaging tumor therapies depends on Bax but not Bak. Monica Zerilli: Th2 cytokines induce chemotherapy resistance in epithelial tumors via PI3K/AKT pathway. Engin Ulukaya: Response of lung cancer patients to cisplatin-based anti-cancer treatments: Effects on the levels of cleaved cytokeratin 18 and sFas . Kerstin Bellmann: The counteracting roles of the kinases Akt/PKB and p38 in c-Myc dependent apoptosis. Emma Sanzari: PED controls B-chronic lymphocytic leukaemia cell apoptosis Arturo Sala: B-MYB regulates the stress response though direct transactivation of key survival genes. Satoshi Inoue: Histone deacetylase inhibitors potentiate TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in lymphoid malignancies.
	13.15 – 15.00: Lunch
	15.00-16.30: Free Time
	16.30-18.00: Cancer II Chairs - Peter Daniel and Engin Ulukaya   Lourdes Planelles: Development of hyperplasia in aged APRIL transgenic mice. Paul Chen: A Role for BAFF in Tumour Immunity. Tobias Haas: Caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs. Eric Eldering: CD40 stimulation increases both the anti- and pro-apoptotic protein profile of B-CLL cells and renders them sensitive to autologous CTL-attack. Till Wenger: Lentiviral expression of TRAIL in human tumor cells.
	18.00-20.00: Posters 29-55
	20.00: Dinner
Saturday 15th May:	7.30 - 9.00:  Breakfast
	9.00 - 11.00: Caspases and their Substrates Chairs- Vincenzo De Laurenzi and Andreas Villunger   Seamus Martin: Understanding the demolition phase of apoptosis. Antoine Tinel: Identification of a caspase-2 activating complex. Thomas Hofmann: FLASH links CD95 (Fas/APO-1) signaling to a novel PML-nuclear body-associated apoptosis pathway. Maya Saleh: Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms. Petra Ovaere: Caspase-14 expression, regulation and processing during epidermal differentiation. Jiang-yan Yang: Partial cleavage of RasGAP by caspases is required for survival in mild stress conditions. Xavier Saelens: Translational control in apoptosis versus necrosis.
	11.00 - 11.30: Coffee break
	11.30 - 13.15: Inhibitor of Apoptosis Proteins Chairs - Seamus Martin and Cristina Munoz-Pinedo   Marion MacFarlane: Caspase activation impedes proteasome function during apoptosis: siRNA targeting of XIAP. Pascal Meier: Ubiquitin-mediated regulation of cell death. Tencho Tenev: Drosophila DIAP1 interacts with caspases through an evolutionarily conserved mechanism that is distinct from XIAP. John Silke: Homeostatic regulation of IAP protein levels. Luis Miguel Martins: Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi. José Rodriguez: A novel role for Survivin-DEx3: regulation of Aurora B sub-cellular distribution during interphase.
	13.15 – 15.00: Lunch
	15.00 - 16.15: Death Receptors I Chairs - Katharina Simon and Henning Walczak   Martin Leverkus: cFLIPL inhibits TRAIL-mediated NF-kB activation and apoptosis induction in human keratinocytes. Gustavo Ortiz-Ferron: Activation of the mitogen-activated protein kinase (MAPK) pathway attenuates TRAIL-induced apoptosis by preventing tBid-mediated release of cytochrome c from mitochondria in breast tumor cells. Martin Sprick: Distinct but overlapping substrate specificities of caspase-10 and caspase-8. Ann Zeuner: Ineffective death receptor signaling in polycythemia vera erythroid progenitor cells.
	16.15 - 16.45: Coffee break
	16.45 - 18.00: Death Receptors II Chairs - Doug Green and Martin Leverkus   Annika Meinander:  Heat stress down-regulates c-FLIP and sensitises cells to Fas receptor-mediated apoptosis. Inna Lavrik: CD95 signaling by the combination of bioinformatical and experimental approaches. Ueli Nachbur: The role of lipid rafts in the regulation of Fas ligand activity. Stefanie Fas: HTLV-1 Tax protects against CD95-mediated apoptosis by induction of the cellular FLICE-inhibitory protein (c-FLIP).
	19.00: Drinks Reception and Gala Dinner
Sunday 16th May:	7.30 - 10.30: Breakfast and departure